Seroepidemiology of dengue virus infection among adults in Singapore.

نویسندگان

  • Yik Weng Yew
  • Tun Ye
  • Li Wei Ang
  • Lee Ching Ng
  • Grace Yap
  • Lyn James
  • Suok Kai Chew
  • Kee Tai Goh
چکیده

INTRODUCTION To determine the seroepidemiology of dengue virus infection in a representative sample of the adult resident population aged 18 years old to 74 years old in Singapore and to estimate the proportion of asymptomatic dengue infection during the 2004 epidemic. MATERIALS AND METHODS The study was based on 4152 stored blood samples collected between September and December 2004 from participants aged 18 years old to 74 years old during the 2004 National Health Survey. Sera were tested for IgG and IgM antibodies using a commercial test kit (PanBio Capture/Indirect ELISA). RESULTS Of the study population, 59.0% and 2.6% tested positive for dengue IgG (past infection) and IgM/high-titre IgG (recent infection), respectively. Only 17.2% of young adults aged 18 years old to 24 years old were dengue IgG positive. Multivariate analyses showed that older age, Indian ethnicity and male gender were significantly associated with past infection, whereas only age was significantly associated with recent dengue infection. Based on the dengue cases notified during the period of survey, it was estimated that for every 23 individuals recently infected with dengue, only 1 was reported to the health authority as a clinical case. CONCLUSION The Singapore population is highly susceptible to dengue epidemics despite its aggressive Aedes prevention and control programme. The finding of a high proportion of unreported cases due to asymptomatic and subclinical infection poses a challenge for dengue control.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Seroepidemiology of Varicella Zoster Virus among Nursing Students in Nursing and Midwifery School of Langeroud

Abstract Varicella is a highly contagious viral infection with self-limiting presentation, yet, it can be more severe in adults. There is a major risk of transmission between health care workers and patients who are susceptible. This study was done to investigate anti-VZV (varicella zoster virus) antibody among nursing students. The anti-VZV IgG was measured in all nursing students in Nursing ...

متن کامل

Seroepidemiology of Hepatitis E Virus in Hemodialysis Patients in Gorgan-Iran

Abstract Background & Objective: Hepatitis E virus is one of the most common causes of acute infection in adults. Pregnant and transplant patients are more in risk of HEV infection. Fecal-oral is the main route of HEV transmission but recently transmission by blood transfusion has been observed. This study was aimed to determine the prevalence of HEV-Ab in hemodialysis patients in Gorgan, I...

متن کامل

Dengue research in Singapore marking the inaugural ASEAN Dengue Day.

1Department of Infectious Diseases, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore 2Environmental Health Institute, The National Environmental Agency, Singapore 3Communicable Diseases Division, Ministry of Health, Singapore Address for Correspondence: A/Prof Leo Yee Sin, Department of Infectious Diseases, Communicable Disease Centre, Tan Tock Seng Hospital, Moulmein Road, Singap...

متن کامل

Seropidemiology of Epstein – Barr virus infection among asymptomatic

Introduction: Epstein – Barr virus (EBV) is a herpesvirus which establishes a persistent life-long infection in over 95% of adults world wide. Infection is usually asymptomatic but the virus is associated with a variety of disease, including nasopharyngeal carcinoma (NPC), Burkitt’s lymphoma (BL), Multiple sclerosis MS, EBV-associated B-cell lymphoproliferative disease (BLPD), Hodgkin and non...

متن کامل

Characterization of dengue virus in Aedes aegypti and Aedes albopictus spp. of mosquitoes: A study in Khyber Pakhtunkhwa, Pakistan

Dengue is a vector-borne disease caused by dengue virus. According to the recent report of CDC that one-third population of the world are at high risk with Dengue fever. The prevalence of the dengue hemorrhagic fever was found more in tropical and sub-tropical regions of the world. Aedes mosquitoes was reported as the main cause of transmission of dengue virus. So the current study was planned ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Annals of the Academy of Medicine, Singapore

دوره 38 8  شماره 

صفحات  -

تاریخ انتشار 2009